We build Biohackn glasses to increase Melatonin
Melatonin is a hormone produced by the brain's pineal gland when the environment becomes dark and is known as the sleep hormone. It is a master antioxidant system that controls inflammation, immune function, and much more. We understand that all cells, organs, and tissues have clocks. One such example would be heart muscle cells, and dysregulation in their timing can put people at risk of high blood pressure, insulin resistance, and many cardiovascular diseases.
Moreover, the supersession of Melatonin can impact sleep and overall antioxidant activity, which results in increased inflammation, a rise in total cholesterol, and a higher risk of cardiovascular diseases.
Melatonin is called the sleep hormone. However, it is one of the most potent antioxidants in our bodies. Melatonin has a diurnal pattern. It lowers down in the morning when the sun is out and rises in the evening when there is less light available from the sun. Looking at artificial blue light has been shown to reduce Melatonin in humans. This happens as the brain misinterprets Sunlight's blue light and signals the master clock in the brain to reprogram all the clocks in the body to work like it is daytime. This effect is also known as is known as the "circadian phase delay effect." There is a natural drop in Melatonin's amount produced by a small gland in the brain called the pineal gland as we age. Lower levels of Melatonin result in less sleep efficiency, a common denominator for aging, and, unfortunately, a common factor in adults and children.
At Biohackn, we primarily focus on increasing melatonin production because Melatonin has immunomodulatory properties (balancing the immune system ). It becomes crucial to remodel the immune system as we age. Our research found Melatonin to be a rejuvenating agent that can improve the severity of a few age-related diseases. After analyzing the data, we found that light at night quickly depletes pineal melatonin production via a melanopsin photopigment pathway.
Diving deep into Melatonin, we found that Melatonin is used by different body cells; some also have melatonin binding sites or receptors. Melatonin is an essential free radical scavenger (Antioxidant ) for reactive oxygen species ( A subtype of free radicals )in the mitochondria. Melatonin can begin an antioxidative cascade by scavenging toxic reactants, and the inability to do this is probably why people age. The phenomenon is commonly known as the R.O.S. or Free radical theory of aging and probably why we are so focused on getting more antioxidants in our diet.
Melatonin and its metabolites have shown functions in scavenging reactive oxygen species and reactive nitrogen species and activating enzymes that remove these potentially toxic agents from the intercellular ( in the cell ) environment, increasing a cell's ability to fight off molecular damage. Animal studies now show that cancer rates rise in subjects exposed to more artificial light at the wrong time of the day.
Melatonin is extremely sensitive to light, and Lights as low as 8 lux, which is just twice the brightness of night light, can reduce melatonin production. One's average computer screen is as bright as 1560 lux. The higher the brightness, the lower melatonin production. We found that Just an hour of exposure to blue light at night can suppress Melatonin by 77%. Most people have sleep issues due to exposure to blue light later in the day. As Melatonin decreases in the brain, it also reduces the calming brain waves such as theta brain waves. Blue light is associated with lowering sleep levels and increasing alpha waves to keep us alert and active.
Our specially designed glasses help filter and block the high-energy blue light spectrum; one of our primary goals is to reduce melatonin suppression when exposed to blue light. When Melatonin is disturbed by exposure to light at night, exposure to blue light can increase breast cancer risk, similar to other diseases such as sleep disorders, jet lag, depression, stress, and immunological disorders. We found Melatonin interesting for cancer because Melatonin acts to counteract tumor formation by reducing cell proliferation.
Higher Melatonin levels ( N-acetyl-5-methoxytrypamine ) reduce MCF-7 cells ( a breast cancer-derived cell line ). In addition, Melatonin has been shown to down-regulate the OESTROGEN ( ESTROGEN) receptor in breast cancer cells and blocks estrogen receptors from binding to different D.N.A. transactivation functions. We believe in naturally reducing the suppression of Melatonin by the protection of the intrinsically photosensitive retinal ganglion cells by providing easy-to-use and simple eyewear. Our aim as a company is to increase melatonin levels. It can protect against breast cancer, reduce oxidative damage by being a potent free radical scavenger, and create antioxidant enzymes.
We chose to help correct people's circadian rhythms. We found that many diseases, such as cancer initiation, promotion, and progression, including invasion and metastasis, are regulated by a person's circadian rhythm. Moreover, these rhythms play an essential role in the molecular processes and gene expression of specific clock proteins involved in cell cycle regulation, cell proliferation, cell survival, apoptosis, D.N.A. damage/ repair, tumor suppression/promotion.
Melatonin plays a crucial role in anti-cancer mechanisms and is regulated by the amount of light exposure. The pineal gland secretes Melatonin in response to environmental light. At Biohackn, we designed our glasses to boost melatonin production at night, even in a brightly lit environment, and to be able to properly synchronize the master clock in the brain along with various peripheral clocks ( body clocks) in the cells and organs. By increasing nighttime Melatonin, we can signal the cells and organs that it is nighttime and can help organize target organs and organ systems to function normally. Thus, we aim to reduce the level of circadian disruption, which can lead to many diseases.
In recent studies, disruption of Melatonin circadian timing by exposure to light at night plays a vital role in developing, promoting, and progressing breast cancer. Moreover, we have seen data showing that artificial light at night can impact the expression of specific clock genes such as Period 1 ( Per1) and period 2 ( Per2), a known tumor suppressor in the organs and tissues as the breast tissue. Looking at the science, we learned that many of the anti-cancer effects of Melatonin are primarily by binding to 2 membrane-associated G protein-coupled receptors (GPCRs).
These are MT1 melatonin receptors encoded by the MTNR1 gene and MT2 encoded by the MTNR1 B. Activation of the MT1 receptor has been shown to affect many biochemical pathways associated with tumor cells, such as inhibition of Forskolin-stimulated cAMP formation, suppression of protein kinase A (aka) activity, and phosphorylation of the camp- responsive element-binding protein (CREB).
Since Melatonin has anti-cancer properties, it is crucial we as a society try to reduce its disruption by exposure to less artificial light at night. However, since shift work and artificial light are part of our modern culture, we decided to Biohackn the environmental light at night by designing eyewear filters and blocking the harmful blue light.